Caffeine, my bestie

This is my advantage to thinking faster, exercising harder, and possibly living longer. With that said, all of you asking me to post my knowledge about this wonderful stimulant, here's everything you'll need to know...

By now you'd think that scientists could close the book on caffeine and move on to other mysteries, like why anyone would ever order a chai latte. After all, coffee and related beverages have been revving people up since, oh, the 15th Century. And in the past 60 years, researchers have conducted over 21,000 studies on my favorite stimulant. That's an average of one new study a day through all of those decades. (Those nutrition scientists may have gotten into their own stash.)

If we don't know caffeine by now, you may well ask, when will we know it? And do I have time for a fix while I'm waiting?



Make it a venti, and sit down. I'll explain a few things. First off, caffeine is a complex compound. And it's made even more so by American's preferred delivery method, coffee. For instance, caffeine raises blood pressure, but habitual coffee drinkers are half as likely to die of heart failure as those who don't fill their mug daily. And while caffeine spikes blood sugar, a java habit may help you dodge diabetes.

Confused? Then use this primer to learn how to consume caffeine to your advantage; at work, in the gym, and for overall health.

chemical structure of caffeine

THE BIOLOGY BEHIND CAFFEINE
To understand how a double espresso can take you from dead tired to completely wired, you first need an introduction to the compound adenosine. Right now, adenosine is coursing through your veins, and its job is to put the brakes on your central nervous system. You might call it nature's chill pill. That's because as your day progresses, adenosine builds up naturally in your bloodstream, causing you to slow down and become sleepier -- a convenient way to let you know it's time to turn off Conan and recharge your batteries.

Adenosine accomplishes this total-body shutdown by plugging into adenosine receptors (think: electrical cords in outlets). These connections inhibit the release of neurotransmitters, which are chemical messengers that control both brain and muscle function. As a result, both your mind and your body slow down.

But as it turns out, caffeine is an excellent adenosine impersonator. In fact, when the two rivals jockey for the same parking space, caffeine wins. If caffeine is plugged into the adenosine receptors, adenosine can't do its job. And this causes your central nervous system to run at a faster rate. Thus you experience the classic and often sought-after caffeine jolt. Here's how to make it work for just about every part of your body.



caffeine jumpstarts short-term memory in the anterior cingulate cortex

YOUR BRAIN
Science: Soon after your first sip, caffeine beings to work its magic by causing the release of dopamine. Dopamine is a brain chemical that stimulates the are of your gray matter responsible for alertness, problem solving, and pleasure. You have that feeling of being activated, sharper, and on the ball. And you can also experience a mild mood-elevating effect. All of which goes a long way in explaining why there are around 9,000 Starbucks outlets in the United States, and more opening every day around the world.

Smarter Instantly: Down a cup of joe just before your next meeting -- it'll boost your mind power for about 45 minutes, according to a recent Austrian study that directly measured the impact of 100 mg of caffeine on brain activity.

Smarter for Life: Refill your cup three times a day. Harvard researchers have determined that men who drink 4 cups of caffeinated coffee a day are half as likely to develop Parkinson's disease as those who skip java -- presumably because caffeine keeps dopamine molecules active. What's more, blocking adenosine may slow the buildup of amyloid-beta, a toxic brain plaque associated with Alzheimer's disease.




YOUR HEART
Science: Adenosine helps blood vessels relax. But once caffeine infiltrates the receptors that line vessel walls, your arteries constrict, causing your blood pressure to rise. In fact, research has shown that blood pressure may increase by as much as 10 points in nonhabitual drinkers. Yet when Harvard researchers tracked the coffee intake of more than 128,000 people, they determined that six cups of coffee a day didn't boost the chance of developing heart disease. And last year, scientists at Brooklyn College found that men who drank 4 cups of caffeinated coffee daily had a 53 percent lower risk of dying of heart disease than those who never took a sip.

If you don't have hypertension to begin with, the temporary blood-pressure increase from a cup of coffee isn't a problem. Plus, the impact on blood pressure sure tends to be smaller in habitual caffeine drinkers because their bodies become somewhat tolerant to its effects.

What About my Health History? If caffeine makes your heart race or skip beats, you're probably genetically sensitive to the stimulant. Although this may sound serious, symptoms such as palpitations are actually considered innocuous, unless you've had a recent heart attack -- I would still suggest you play it safe and use this rule of thumb: If you think you're caffeine-sensitive, consult your physician to determine if you should limit your intake.

Drink Antioxidant-Rich Java: Scientists aren't sure whether it's the caffeine or the antioxidants in coffee -- or a combination of the two -- that provided the aforementioned cardiovascular benefits. But unless you're caffeine-sensitive, go with the leaded variety. Research shows that antioxidant levels are decreased by about 15 percent in decaf.




YOUR MUSCLES
Science: Because caffeine revs up your central nervous system, it slightly increases your heart rate and breathing rate, both of which help prepare your body for peak performance. Caffeine may also have a direct effect on your muscles. Here's how: Calcium must be released within a muscle fiber in order for that fiber to contract, and caffeine may block the adenosine receptors attached to muscle fibers, triggering electrical activity that prompts bigger burst of calcium. The result is a stronger muscle contraction.

Jumpstart Your Workout: Studies show that consuming 140 to 400 mg of caffeine 30 to 60 minutes prior to exercise can improve both speed and endurance and make your workout seem easier. But to achieve those effects, researchers have used either caffeine pills or caffeinated soda. The reason: Many pills other chemical compounds in coffee appear to counteract caffeine's ability to impact your exercise session. Now you know why energy drinks were created. Looking for a boost? Try Celsius, which is sugar-free and contains about 200 mg of caffeine per 12-oz. can. To determine if it's enhancing your performance, be sure to monitor how it impacts your exercise session both mentally ("My exercise seems easier" or "I felt I was dragging") and physically ("I completed more repetitions" or "I didn't improve").

CAUTION! If you have heart problems or a family history of heart disease, avoid high-caffeine drinks for 4 hours before exercising. A 2006 study in the Journal of American College of Cardiology determined that 200 mg of caffeine decreases bloodflow to the heart by up to 39 percent during exercise because it constricts coronary arteries.




YOUR LIVER
Science: When your central nervous system is activated, so is your body's fight-or-flight response. This causes the release of stress hormones such as cortisol and adrenaline. These in turn signal your liver to pump sugar into your bloodstream. After all, had you been in a truly stressful situation -- say, face-to-face with a cranky barista -- your body would need that sugar for quick energy. But in everyday life (read: sitting at your desk), extra blood sugar is the last thing you need, because it signals your body to store fat and increases your risk of diabetes.

Keep Your Blood Sugar in Check! Forgo the sugar in your coffee and you'll actually reduce your risk of developing diabetes according to mulitple studies. For example, in 2005, Harvard University researchers determined that drinking 5 cups of coffee a day cuts in half the risk of developing diabetes. Scientists aren't sure why coffee may have a protective effect against diabetes, but credit its high levels of disease-fighting antioxidants. While visiting Starbucks, if you want something healthy (and cheap) go with a Caffe Americano (Grande size) -- this is coffee at its finest: strong and flavorful, but sugar-free.


Caffe Americano